Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3
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چکیده
منابع مشابه
Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.
The lysine acetylation state of nonhistone proteins may be regulated through histone deacetylases (HDACs). Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium. We tested the hypothesis that NOS3 is lysine acetylated and that upregulated HDAC1-mediated deacetylation leads to re...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2014
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00243.2014